Over-the-Counter Sleep Aids Comparison

Notice: While these medications don't require a prescription, it's still important to follow dosage instructions and consult with a healthcare provider before use.

Product Type Onset Time Duration Strength Side Effects Cost Best For
Doxylamine (Unisom) Antihistamine 30 minutes 6-8 hours Moderate Moderate $ Occasional insomnia
Diphenhydramine (Benadryl) Antihistamine 15-30 minutes 4-6 hours Moderate Moderate $ Short-term use
Melatonin Hormone 30-60 minutes 4-8 hours Mild Minimal $ Jet lag, shift work
Valerian Root Herbal 60-90 minutes 4-6 hours Mild Minimal $$ Mild sleep issues

Usage Guidelines

  • Start with lowest effective dose
  • Don't exceed recommended dosage
  • Avoid long-term daily use
  • Don't combine with alcohol
  • Stop use if side effects occur

When to See a Doctor

  • Sleep problems lasting >2 weeks
  • Severe daytime drowsiness
  • Unusual sleep behaviors
  • Worsening sleep issues
  • Other health concerns